Cannabinoids have a strong affinity for fat and accumulate in cerebral fat, acting as a reservoir of THC in adipose tissue. The sympathetic nervous system becomes activated during starvation or heightened physical stress. This results in elevated adrenocorticotropic hormone (ACTH) action on adipocyte receptors, causing lipolysis to meet bodily demands 50. Lipolysis from elevated ACTH triggers the release of THC from fat cells. This leads to high THC concentrations, particularly after consuming potent cannabis, which explains its pro-emetic effects 51.

The importance of quitting cannabis with CHS

Furthermore, chronic marijuana use has been shown to impair gastric emptying, thereby causing nausea and vomiting after meals 52. This was demonstrated in a study by McCallum et al., where male participants were given either marijuana or a placebo before undergoing a radionuclide gastric emptying test 53. CB2 receptors help to control inflammation, visceral pain, and intestinal motility 34. They are found in lamina propria plasma cells and activated macrophages. Nausea and vomiting are regulated in ECS through central and peripheral pathways 35.

CHS may involve dysfunction in the sympathetic nervous system 49. This is evidenced by symptoms like rapid heartbeat, sweating, hot flashes, high blood pressure, and tremors, often during the hyperemesis phase 49. The endogenous ligands, AEA and 2-AG, are derived from arachidonic acid. 2-AG is mainly located in the brain and is primarily involved in the signaling process. AEA and 2-AG are produced from cell membrane lipids and move to the extracellular space via diffusion, endocytosis, carrier transport, translocation, and possibly heat shock proteins 28. They stimulate the cannabinoid receptors in various brain regions, including the temporal lobe, orbitofrontal cortex, insula, and parahippocampal areas, to produce their effects 29.

How soon after cannabis hyperemesis syndrome treatment will I feel better?

• At Leafy Mate, we are dedicated to empowering you with the knowledge needed to navigate this complex landscape responsibly.
• They start to feel better when they stop using marijuana but can feel bad if they use it again.
• Studies indicate that when patients trust their physicians, they are more likely to disclose sensitive health-related behaviors and adhere to medical recommendations 107.
• Therefore, cultivating a more accepting healthcare environment for patients using cannabis could improve the accuracy of self-reported data and help in the earlier identification of CHS.
• Yet, its relationship with appetite and digestion is far more nuanced, offering potential benefits for weight management, digestive comfort, and overall wellness.
• Camilleri also said that cannabis use is positively correlated with anxiety and depression, and noted that doctors should treat the whole patient and not just the disorder.

Additionally, studies that did not discuss cannabis use in relation to CHS symptoms were not considered. Cannabinoids affect the pituitary–adrenal axis and stress-responsive brain regions. Studies suggest that CHS may involve disruption at the hippocampal–hypothalamic–pituitary level 22. Chronic amphetamine addiction treatment cannabis use can lower pituitary hormone levels, including the growth hormone, follicle-stimulating hormone, and luteinizing hormone, which has been shown to normalize after stopping use 23,24. For thousands of years, cannabis and its derivatives, including hashish, have been utilized for their psychoactive properties 1. It has been found that in 3500 BC, Romanian kurgans burned cannabis for ceremonial practices.

However, this proposed mechanism has not been empirically validated 59. Though many patients with CHS may use hot bathing or showering to obtain relief from its symptoms, more than 10% may not exhibit this behavior 60. Understanding Cannabinoid Hyperemesis Syndrome (CHS) is crucial as cannabis use continues to rise, especially among younger individuals. This complex condition, characterized by severe nausea, vomiting, and abdominal pain, often goes misdiagnosed due to its similarity to other gastrointestinal https://ecosoberhouse.com/ disorders. Recognizing CHS symptoms and seeking timely medical advice is vital, as early intervention can significantly enhance patient outcomes.

Weed Woes: Exploring Cannabis-Induced Sickness

Through compounds like THC, CBD, and THCV, along with aromatic terpenes, cannabis can stimulate or suppress appetite, ease nausea, or support a healthy gut microbiome. If you use cannabis regularly, you could find it difficult to stop due to withdrawal symptoms. While withdrawal from cannabis is generally not considered dangerous, as it can be with other drugs, it can still be unpleasant and difficult. In addition, a small percentage of people who use cannabis regularly can develop marijuana use disorder, including addiction. You need to seek emergency care if you are experiencing severe abdominal pain, prolonged vomiting, or developing signs of dehydration.

• If CHS is suspected, stopping marijuana use is the first crucial step, and seeking treatment for marijuana addiction may be necessary to prevent further complications.
• Tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis.
• It is mainly utilized for treating agitated patients and causes sedative effects at doses of 2 to 10 mg intravenously, with a maximum daily dosage of 30 mg 76.
• Cannabis hyperemesis syndrome (CHS) is a condition that leads to repeated and severe bouts of nausea, vomiting, and abdominal pains.
• Let’s work together to ensure that our choices lead to well-being and safety for everyone.

Smoking extra marijuana won’t help your nausea but will make it worse. Cannabinoid hyperemesis syndrome (CHS) is a very unpleasant — and potentially dangerous — complication of long-term marijuana use. Because of this possible complication, it’s important to use caution with marijuana and other cannabis products. If you think you have CHS or cannabis use disorder, talk to a healthcare provider. Cannabinoid hyperemesis syndrome is an uncommon reaction to cannabis use. In addition to frequent and severe vomiting, patients may have difficulty eating and drinking, and only find (temporary) relief in hot showers and baths.

What are other impacts of cannabis use?

Examples of cannabinoids include tetrahydrocannabinol (THC) and cannabidiol (CBD). CVS tends to have more vomiting than abdominal pain, and abdominal migraine tends to have more pain than vomiting. Each attack is very similar to the others, and they recur after some weeks or months.

At Leafy Mate, we strive to be a supportive resource in navigating these complexities. We connect users with trusted medical marijuana physicians and high-quality marijuana brands. Together, we empower consumers by providing educational resources and guidance to make informed choices about their marijuana use. Contact your health care provider if you have had severe vomiting for a day or more. Once the individual abstains from using cannabis, symptoms gradually decrease. The recovery speed may depend on the severity of physical trauma sustained through chronic vomiting and dehydration.

CBG has the potential to reverse the antiemetic effects of CBD, suggesting that CHS could result from the interplay between high levels of CBD and its reversal by CBG 25,26. After applying these criteria, a selection of relevant studies was included in this narrative review. These studies were analyzed and synthesized to provide an overview of CHS, its clinical features, and the evolving understanding of its relationship to chronic cannabis use. Studies focused on individuals diagnosed with CHS, as well as those with comparable conditions like CVS, were selected. Emphasis was placed on studies that reported on demographic information, symptom patterns, diagnostic criteria, and treatments. Until the past decade, marijuana, specifically THC, had been largely illegal to possess and use, and its legalization has prompted new medical insights into its effects, both positive and negative.

• Have you or someone you know experienced these troubling symptoms?
• Like gastritis, ulcers can feel worse on an empty stomach and feel better after antacids.
• These include intense nausea, frequent vomiting, abdominal discomfort, and an unusual urge to bathe.
• Both cannabinoid hyperemesis syndrome (CHS) and cyclic vomiting syndrome (CVS) cause people to feel sick to the stomach and throw up at times, while feeling normal at other times.

Doxepin is generally better tolerated and is started at a dose of 10 mg. The dose can be gradually increased in 10 mg increments every 1–2 weeks until the G.I. Cardiac arrhythmias have not been observed with gradual dose titration. Amitriptyline is initially started at a low dose of 10 mg at night and gradually increased to 10 mg every 1–2 weeks until the therapeutic effect is achieved 96. Additionally, gradual titration of the dose prevents cardiac arrhythmias. TCA is used in caution with underlying cardiac arrhythmias, recent myocardial infarction, mania, or severe liver disease 97.

Discover the Benefits of 2 Gram Cart for Cannabis Consumers

And primary care providers, are vital in diagnosing and treating CHS as its prevalence rises. This will provide more data on CHS and facilitate the development of targeted novel therapeutic interventions for this condition in the future. Also, future longitudinal research exploring genetic predisposition and biomarkers could aid in diagnosing and treating CHS.